thanks guys, what i meant was for properly fitted clubs, would the golfer with more upright lie angles have any anti-slice bias vs the one with the flatter clubs. i play with very upright wedges and irons and they fit me well, but i am aware there are some slight differences between upright and flat based on the geometry of the d-plane.
for example, the upright swinger will tend to have a clubpath and clubface squarer to the target line longer, but will also have a steeper path into and out of impact. (croquet mallet)
the flat swinger will have a clubpath and clubface that aren't square to the target as long, but won't be as steep near contact. (pinball flipper)
i've never seen data on the magnitude of these differences and if they are large enough to make any difference in a real world golf swing, although i've heard some people make arguments that history's best ballstrikers have tended to have flat clubs.